About 2.7 percent of women will be diagnosed with endometrial cancer at some point during their lifetime, based on the SEER 2008-2010 data.
Endometrial cancer is the most common malignancy of women in developed countries, and its incidence is 10 times higher than in developing countries.
81.1% of women with endometrial cancer have a 5 year survival rate.
Endometrial cancer is heavily influenced by estrogen exposure, therefore it is found in higher amounts in women with early start of menstrual cycle, no children and late menopause.
A number of risk factors are known to be associated with endometrial cancer occurrence, with different risk factors among different age groups. Endometrial cancer occurs much more frequently in post- menopausal women. Among the most well-established risk factors include:
Risk factors for older women:
Other known risk factors include:
Physical symptoms There is not one lab test to diagnose endometrial cancer, rather it is most often suspected from initial physical exam and history. It is estimated that 90% of women with endometrial cancer experience changes in their menses, vaginal bleeding, or experience post-menopausal vaginal bleeding and 10% of endometrial cancers present as a non-blood discharge. Later stages of the cancer may show up as pain in the pelvis, feeling a mass in the abdomen or pelvis, and losing weight without trying.
Noninvasive methods: Ultrasound of the pelvic region and endometrial cytology (cell study).
Invasive methods: Dilatation and curettage (D&C); endometrial biopsy and hysteroscopy with biopsy of the endometrium (uterine lining).
Multiple nutritional supplements have been associated with reduced cancer incidence and/or cancer progression. The list below contains those with the greatest evidence-base and benefit, though it is not necessary that they all be included.
 Matsuo K, Cahoon SS, Gualtieri M, Scannell CA, Jung CE, Takano T, Paulson RJ, Muderspach LI, Roman LD. Significance of Adenomyosis on Tumor Progression and Survival Outcome of Endometrial Cancer. Ann Surg Oncol. 2014 Jul 8.
 Ali AT. Reproductive factors and the risk of endometrial cancer. Int J Gynecol Cancer. 2014 Mar;24(3):384-93.
 Furness S, Roberts H, Marjoribanks J, Lethaby A. Hormone therapy in postmenopausal women and risk of endometrial hyperplasia. Cochrane Database Syst Rev. 2012 Aug 15;8:CD000402.
 Moore LL1, Chadid S2, Singer MR2, et al. Metabolic Health Reduces Risk of Obesity-Related Cancer in Framingham Study Adults. Cancer Epidemiol Biomarkers Prev. 2014 Jul 10. pii: cebp.0240.2014. [Epub ahead of print]
 Keum N, Ju W, Lee DH, Ding EL, Hsieh CC, Goodman JE, Giovannucci EL. Leisure-time physical activity and endometrial cancer risk: dose-response meta-analysis of epidemiological studies. Int J Cancer. 2014 Aug 1;135(3):682-94.
 Arem H, Neuhouser ML, Irwin ML, Cartmel B, Lu L, Risch H, Mayne ST, Yu H. Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. Eur J Nutr. 2013 Apr;52(3):1251-60.