Endometrial Cancer Supplement Recommendations

Multiple nutritional supplements have been associated with reduced cancer occurrence and/or cancer progression. The list below contains those with the greatest evidence-base and benefit, though it is not necessary that they all be included.

Vitamin D

  • Vitamin D levels are associated with the risk of most hormone cancers, including endometrial cancers. Studies on human cells demonstrate that vitamin D protects against endometrial cancer progression.[1],[2]Individuals with a history of lymphoma should also monitor 1,25 dihydroxy-vitamin D levels, as rapid conversion to this active form has been observed.
  • Suggested dose is that sufficient to raise vitamin D blood levels to >40 ng/mL, which may require 5000 IU per day or more.[3]

Scutellaria baicalensis

  • Used as an adjunctive to chemotherapy for lung cancer patients, cell-based studies have demonstrated that Scutellaria inhibited NFκB formation, which could be beneficial to slow endometrial cancer.[4]
  • Suggested dose: Dried herb: 1 to 2 grams 3 times per day; Tea: 240 mL 3 times per day or as a tincture: 2 to 4 mL 3 times per day.

Agaricus Blazei

  • Agaricus is a mushroom extract used in Chinese medicine for anti-tumor affects, potentially as a result of the beta glucan content. A group of women with gynecological cancers were given Agaricus extract along with chemotherapy for at least 3 weeks for 3 cycles and the women on the mushroom had higher natural killer cell activity.[5]
  • Suggested dose: 400mg Agaricus Blazei extract per day, containing 160 mg polysaccharides (approximately 25% beta glucans).

Lycopene

  • Lycopene has been used as an immune stimulant in a variety of cancers. Blood levels of lycopene were found to be inversely related to the risk of developing endometrial cancer in a group of females.[6] Additionally, cell studies show that lycopene can inhibit cancer progression in estrogen affected cancer cells, such as the endometrial cells.[7]
  • Suggested dose: 30mg per day.

Beta carotene

  • Beta carotene has been used as an immune stimulant in many disease states as well as cancer. Blood levels of beta carotene were found to be inversely related to the risk of developing endometrial cancer in several studies upon review of intake and cancer development.[8],[9] Furthermore endometrial cancer was inhibited in cells treated with beta carotene and other carotenoids.[10]
  • Suggested dose: Experts recommend as high as starting at 10,000 IU per day up to 83,000 IU per day

Green tea extract

  • Catechins, antioxidants found in green tea, particularly EGCG (epigallocatechin-3-gallate), are known to have numerous anti-metastatic and anti-proliferative properties in cancers that are affected by estrogens. Cell studies demonstrated that EGCG inhibits cellular proliferation via inhibiting ERK activation and induces apoptosis (cell death) in endometrial carcinoma cells.[11][12]
  • Suggested dose: 1g EGCG and mixed catechins.

Omega-3 fatty acids

  • Omega-3 fatty acids, DHA and EPA, have been shown to exert numerous anti-cancer effects on breast cancer cells. Human studies are limited on endometrial cancer but one did recently establish that dietary PUFA and DHA inhibited endometrial cancer cell proliferation, colony formation, and migration, and promoted cell-programmed death (apoptosis) in animal and in-vitro models.[13] Additionally, GLA, another omega-3, helps to maintain balance in the fatty acids and enhances the anti-inflammatory effect.[14],[15]
  • Suggested dose: 2-3 grams combined EPA & DHA per day, with at least 1-2 grams of a GLA source.

 

← Back to Endometrial Cancer Wellness Plan

 

Vitamins

Get the Supplements

Our partner company, Solutions 4 Health, carries many of these supplements in their online store. Click below to find out more.

SHOP NOW

 

[1] Bergadà L, Pallares J, Vittoria Arcidiacono M, Cardus A, Santacana M, Valls J, Cao G, Fernàndez E, Dolcet X, Dusso AS, Matias-Guiu X. Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma. Lab Invest. 2014 Jun;94(6):608-22. doi: 10.1038/labinvest.2014.57. Epub 2014 Apr 14.

[2] Nguyen H, Ivanova VS, Kavandi L, Rodriguez GC, Maxwell GL, Syed V. Progesterone and 1,25-dihydroxyvitamin D₃ inhibit endometrial cancer cell growth by upregulating semaphorin 3B and semaphorin 3F. Mol Cancer Res. 2011 Nov;9(11):1479-92.

[3] Garland CF, French CB, Baggerly LL, et al. Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer Res. 2011 Feb;31(2):607-11.

[4] Kavandi L, Lee LR, Bokhari AA, Pirog JE, Jiang Y, Ahmad KA, Syed V. The Chinese herbs Scutellaria baicalensis and Fritillaria cirrhosa target NFκB to inhibit proliferation of ovarian and endometrial cancer cells. Mol Carcinog. 2013 Nov 19.

[5] Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94.

[6] Jeong NH, Song ES, Lee JM, Lee KB, Kim MK, Yun YM, Lee JK, Son SK, Lee JP, Kim JH, Hur SY, Kwon YI. Preoperative levels of plasma micronutrients are related to endometrial cancer risk. Acta Obstet Gynecol Scand. 2009;88(4):434-9.

[7] Hirsch K, Atzmon A, Danilenko M, Levy J, Sharoni Y. Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells. Breast Cancer Res Treat. 2007 Aug;104(2):221-30.

[8] Jeong NH, Song ES, Lee JM, Lee KB, Kim MK, Yun YM, Lee JK, Son SK, Lee JP, Kim JH, Hur SY, Kwon YI. Preoperative levels of plasma micronutrients are related to endometrial cancer risk. Acta Obstet Gynecol Scand. 2009;88(4):434-9.

[9] Pelucchi C, Dal Maso L, Montella M, Parpinel M, Negri E, Talamini R, Giudice A, Franceschi S, La Vecchia C. Dietary intake of carotenoids and retinol and endometrial cancer risk in an Italian case-control study. Cancer Causes Control. 2008 Dec;19(10):1209-15.

[10] Hirsch K, Atzmon A, Danilenko M, Levy J, Sharoni Y. Lycopene and other carotenoids inhibit estrogenic activity of 17beta-estradiol and genistein in cancer cells. Breast Cancer Res Treat. 2007 Aug;104(2):221-30.

[11] Manohar M, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A. (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation. J Nutr Biochem. 2013 Jun;24(6):940-7.

[12] Park SB, Bae JW, Kim JM, Lee SG, Han M. Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. Int J Mol Med. 2012 Nov;30(5):1211-8.

[13] Zheng H, Tang H, Liu M, He M, Lai P, Dong H, Lin J, Jia C, Zhong M, Dai Y, Bai X, Wang L. Inhibition of Endometrial Cancer by n-3 Polyunsaturated Fatty Acids in Preclinical Models. Cancer Prev Res (Phila). 2014 May 27.

[14] Xu Y, Qian SY1. Anti-cancer activities of ω-6 polyunsaturated fatty acids. Biomed J. 2014 May-Jun;37(3):112-9.

[15] Biomed J. 2014 May-Jun;37(3):112-9. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Int J Cancer. 2000 Mar 1;85(5):643-8.

Follow Us